Update on long QT syndrome

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The congenital long QT syndrome Type 3: An update

Congenital long QT syndrome type 3 (LQT3) is the third in frequency compared to the 15 forms known currently of congenital long QT syndrome (LQTS). Cardiac events are less frequent in LQT3 when compared with LQT1 and LQT2, but more likely to be lethal; the likelihood of dying during a cardiac event is 20% in families with an LQT3 mutation and 4% with either an LQT1 or an LQT2 mutation. LQT3 is ...

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T he idiopathic long QT syndrome (LQTS) is a congenital disease with frequent familial transmission, characterized primarily by prolongation of the QT interval and by the occurrence of life-threatening tachyarrhythmias, particularly in association with emotional or physical stress.1-5 Among untreated symptomatic patients, lethality is high, with 20% mortality in the first year after the initial...

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Background. Erythromycin is known to prolong ventricular repolarization and has been associated with the occurrence of torsades de pointes. In this study, we have investigated potential mechanisms in vivo and in vitro for induction of an acquired long QT syndrome by erythromycin. Methods and Results. Ventricular electrograms and endocardial monophasic action potentials were recorded in anesthet...

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Introduction The Long QT syndrome (LQTS) can be inherited or acquired and is of particular interest and concern at present. Patients with LQTS are predisposed to the ventricular tachyarrhythmia torsade de pointes (TdP) which causes syncope and sudden death. Inherited LQTS is the prototype of the "primary cardiac arrhythmias" or "cardiac ion channelopathies". The study of inherited LQTS has prov...

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Department of Biology, National Taiwan Normal University, Taipei; Department of Internal Medicine, Chang Gung Memorial Hospital and Chang Gung University, Taipei; Department of Internal Medicine, Wei Gong Memorial Hospital, Tou Fen, Miaoli; Division of Cardiology, Department of Medicine, Veterans General Hospital-Taipei; and Department of Medical Research and Education, Veterans General Hospita...

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ژورنال

عنوان ژورنال: Journal of Cardiovascular Electrophysiology

سال: 2019

ISSN: 1045-3873,1540-8167

DOI: 10.1111/jce.14227